2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W181626
    Tiprenolol 26481-51-6 98%
    Tiprenolol is a β-adrenoceptor blocker. Tiprenolol can abolish the ventricular arrhythmias produced by adrenaline in dogs respired with halothane.
    Tiprenolol
  • HY-W184837
    m-Nisoldipine 113578-26-0 98%
    m-Nisoldipine (KR-1008) is a dihydropyridine calcium antagonist that can significantly increase cardiac output and heart index, significantly reduce the negative inotropic effect on the myocardium, and has a relatively high selectivity for the thoracic aorta. m-Nisoldipine can be used in the research of cardiovascular diseases.
    m-Nisoldipine
  • HY-W187973
    3-Methylchromone 85-90-5 98%
    3-Methylchromone is an active compound which can be used in the prevention and research of anginose attacks of coronary origin.
    3-Methylchromone
  • HY-W192276
    (±)-Desisopropylpropranolol 20862-11-7 98%
    (±)-Desisopropylpropranolol (N-Desisopropylpropranolol) is a metabolite of Propranolol (HY-B0573B). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Kis of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
    (±)-Desisopropylpropranolol
  • HY-W193398
    N-2-Cyclohexylethyl-N-methylamine 62141-38-2 98%
    N-2-Cyclohexylethyl-N-methylamine is an amine from A.ridigula Benth for a reduction of monoamine oxidase (MAO) activity.
    N-2-Cyclohexylethyl-N-methylamine
  • HY-W223348
    Org-9768 759424-59-4 98%
    Org-9768 ((2-methyl-2,3-dihydro-1H-inden-2-yl)methanamine) is a drug intermediate for synthesizing the mitochondrial permeability transition pore (mPTP) inhibitor. Org-9768 can be used for the researches of neurological and cardiovascular disease, such as Parkinson's disease.
    Org-9768
  • HY-W263279
    (E)-Guanabenz 60329-03-5 98%
    (E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease.
    (E)-Guanabenz
  • HY-W273690
    Pentifylline 1028-33-7 99.23%
    Pentifylline is a vasodilator with anti-inflammatory activity. Pentifylline inhibits platelet aggregation and thromboxane A2 synthesis, reduces the release of free radicals, and decreases the production of type 1 collagen and laminin in fibroblasts. Pentifylline has the potential to be studied in acute ischemic stroke.
    Pentifylline
  • HY-W319332
    Necrostatin-21 169136-33-8 98%
    Necrostatin-21 (Compound Nec-21) is a necroptosis inhibitor with an EC50 of 0.5 μM. Necrostatin-21 has a dual inhibitory effect on the RIP1 and JNK3 kinases. Necrostatin-21 can be used for the researches of infection, cardiovascular and neurological disease, such as Alzheimer disease .
    Necrostatin-21
  • HY-W328882
    3-(2-Aminopropyl)phenol 1075-61-2 98%
    3-(2-Aminopropyl)phenol is a biologically active compound with significant blood pressure-raising activity. 3-(2-Aminopropyl)phenol can effectively improve the symptoms of orthostatic hypotension in patients. 3-(2-Aminopropyl)phenol can significantly increase blood pressure at rest and when standing after oral administration. 3-(2-Aminopropyl)phenol can help reduce pathological orthostatic adjustment disorders. 3-(2-Aminopropyl)phenol has a relatively small effect on heart rate, and no significant side effects have been observed.
    3-(2-Aminopropyl)phenol
  • HY-W349178
    Medorinone 88296-61-1 98%
    Medorinone is an inhibitor of cAMP phosphodiesterase activity. Medorinone can be used as a cardiac stimulant/vasodilator.
    Medorinone
  • HY-W349716
    LM-1554 89567-03-3 98%
    LM-1554 is an orally active antihyperlipaemic agent. LM-1554 can inhibit cholesterol absorption in the gastrointestinal tract.
    LM-1554
  • HY-W353225
    Pyricarbate 1882-26-4
    Pyricarbate (Pyridinol carbamate) is an orally active 2,6-pyridine dimethanol biscarbamate with cholesterol-lowering and antiatherosclerotic effects.
    Pyricarbate
  • HY-W396714
    Succinic acid sodium 14047-56-4 98%
    Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research.
    Succinic acid sodium
  • HY-W401947
    Isosorbide 2-Nitrate 16106-20-0 98%
    Isosorbide 2-Nitrate is a nitrate that acts as a vasodilator. Isosorbide 2-Nitrate acts by releasing nitric oxide, which subsequently activates guanylate cyclase in smooth muscle cells.
    Isosorbide 2-Nitrate
  • HY-W412326
    Guaietolin 63834-83-3 98%
    Guaietolin is an organic synthesis intermediate. Guaietolin is a marker of hypertension with significant reduced level in plasma metabolites. Guaietolin can be used for synthesis of sulfonamide esters with carbonic anhydrase inhibitory activity. Guaietolin can be used for glaucoma and hypertension research.
    Guaietolin
  • HY-W414915
    Valsartan methyl ester 137863-17-3 99.39%
    Valsartan (CGP 48933) methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure.
    Valsartan methyl ester
  • HY-W424839
    Probucol dithiobisphenol 6386-58-9 98%
    Probucol dithiobisphenol (DTBP) is the derivative of Probucol (HY-B0388). Probucol dithiobisphenol induces the production of heme oxygenase 1 (HO-1), and exhibits antioxidant activity. Probucol dithiobisphenol inhibits atherosclerotic lesions in Apoe−/− mice aorta, promotes re-endothelialization of aorta and inhibits restenosis in rabbit arterial injury models. Probucol dithiobisphenol is orally active.
    Probucol dithiobisphenol
  • HY-W436366
    SSR180575 220448-02-2 98%
    SSR180575 is a specific and potent peripheral benzodiazepine receptor ligand. SSR180575 irreversibly and specifically binds with high affinity on rat heart mitochondria (Kd = 1.95 nM). SSR180575 can be used in the research of cardiovascular diseases.
    SSR180575
  • HY-W471937
    α1B-AR antagonist 1 874129-03-0 98%
    α1b-AR antagonist 1 (Compound Cpd1) is a selective α1B-AR antagonist. Alpha1b-ar antagonist 1 can be used in the study of cardiovascular and central nervous system diseases.
    α1B-AR antagonist 1
Cat. No. Product Name / Synonyms Application Reactivity